Chemical and Biological Material Safety Publications


Topic Title Organizaton Pub Date
Anhydrous Ammonia Safety: Play it Safe with Anhydrous Ammonia Iowa State University Extension and Outreach 2008
Farm Family Exposure to Pesticides: A Discussion with Farm Families Purdue Extension 2007
Handling Pesticides Safely University of Maine Extension 2020
Laundering Pesticide-Contaminated Clothing University of Missouri Extension 2010
Laundering Pesticide-Contaminated Clothing University of Maine Extension 2002
Learn about Pesticides and Clothes Iowa State University Extension and Outreach 2002
Master Gardeners’ Safety Precautions for Handling, Applying, and Storing Biochar Iowa State University 2012
Pesticides and Their Toxicity University of Maine Extension 2020
Personal Protective Equipment for Pesticide Handlers University of Maine Extension 2020
Personal Protective Equipment for Working with Pesticides University of Missouri Extension 2001
Pesticide Poisoning Symptoms and First Aid University of Missouri Extension 2002
Using Pesticides Safely Around the Home University of Missouri 2007

Chemical Safety Video Resources


Topic Titles Organization  Resource Types

Anhydrous Ammonia Safety (2009)

11:38 minutes

Illinois Department of Agriculture Free – Online Video via Vimeo

Exposicion a Pesticidas, Senalas y Sintomas


1:46 minutes

U.S. Agricultural Safety and Health Centers Free – Online Video via YouTube

Pesticide Safety (2015)

Series of 6 videos – English and Spanish

U.S. Agricultural Safety and Health Centers Free – Online Video via YouTube

Pesticides Safe and Easy (2009)

8:47 minutes

New Mexico State University Free – Online Video via YouTube

Pesticide Safety (2011)

2:31 minutes

Canadian Agricultural Safety Association Free – Online video via YouTube

Protective Clothing and Equipment for Pesticide Use (2000)

14:14 minutes

Ontario Pesticide Education Free – Online video via YouTube


Anhydrous Ammonia Safety

Anhydrous Ammonia

(Source: Pennsylvania State University. Agricultural Safety and Health)

Use the following format to cite this article:

Anhydrous ammonia safety. (2012) Farm and Ranch eXtension in Safety and Health (FReSH) Community of Practice. Retrieved from


Anhydrous ammonia (NH3) is a nitrogen crop fertilizer that can cause severe chemical burns; frostbite to the eyes, skin, and respiratory tract; and death. It is important for all individuals working with this type of fertilizer to understand the potential risks, necessary safety precautions, and proper response in the event of accidental contact.

Anhydrous ammonia is a hygroscopic compound, meaning that it takes up water from the nearest source, which can include the human body—especially the eyes, lungs, and skin because of their high moisture content. Anhydrous ammonia is caustic, corrosive, and damaging to tissue high in moisture content when it contacts the human body. Anhydrous ammonia inhalation incidents are typically severe because the victim’s throat can swell shut, causing suffocation. When vapors or liquid come in contact with a person’s eyes, blindness may occur.

Typically, anhydrous ammonia is stored under pressure, but it vaporizes to a colorless gas. It has a unique odor that can be detected at a low concentration of 5 ppm. The concentration in fertilizer is approximately 1,000,000 ppm, but even brief exposure to a concentration of 2,500 to 6,500 ppm can result in death.

Anhydrous ammonia is transported under pressure as a liquid, so all equipment used for transport must be designed for use under high pressure to avoid ruptures or breaks. Incidents can occur when anhydrous ammonia escapes from transfer hoses or valves, equipment malfunctions and sprays anhydrous ammonia in multiple directions, hoses pull apart during transportation or application, and so on.

PPE and Supplies

It is essential that all workers who use anhydrous ammonia wear the appropriate personal protective equipment (PPE), be equipped with necessary response supplies, and know how to respond in an emergency. PPE should include ventless goggles or a full-face shield, rubber gloves with long cuffs that can be rolled to catch drips, and a long-sleeved shirt. Nonrubber gloves made of ammonia-proof material are acceptable. Because contact lenses can trap the gas and become fused to the eye, it is recommended that individuals not wear contact lenses while working with anhydrous ammonia.

In the event of an exposure emergency, the most important resource is an ample supply of clean water to begin flushing the eyes and skin. If you use a vehicle to transport anhydrous ammonia, you must carry a 5 gal. container of clean water. Each person working with anhydrous ammonia should carry a 6 to 8 fl. oz. squeeze bottle of water at all times for rapid response to an emergency.

Basic First Aid for Anhydrous Ammonia Exposure

The first-response treatment for anhydrous ammonia exposure is to flush the exposed area (skin, nose, throat, eyes, and so on) with clean water for a minimum of 15 minutes.

  • Flush the exposed area immediately to decrease injury caused by the anhydrous ammonia coming in contact with skin or clothes. Although clean water is the ideal resource for flushing exposed areas of the body, if you do not have water available, other nontoxic liquids, such as cold coffee or orange juice, can be used.
  • Remove contaminated clothing unless the clothing is frozen to the victim’s skin.
  • Seek medical attention immediately and inform medical staff of the exposure to anhydrous ammonia so that they will not treat the wounds with oils or ointments that can intensify the damage.

If you find a person who is in a continuous stream of anhydrous ammonia, contact your local emergency service responders or 911. Inform the emergency medical responders about the type of incident so they can bring the proper equipment to the scene. A self-contained breathing apparatus (SCBA) and protective clothing are necessary to remove a person from a continuous stream. Rescue workers will contact a hazardous materials (HAZMAT) disposal team if HAZMAT services are needed at the scene.

Note that these guidelines are not comprehensive, and all individuals working with anhydrous ammonia should receive training in the proper response to exposure emergencies.

Storage and Transportation

Anhydrous ammonia is a strong alkali that, when dissolved in water, readily reacts with copper, zinc, brass, and other alloys. Therefore, the only types of containers, fittings, and piping that should come in contact with anhydrous ammonia should be nongalvanized steel or iron. Do not store other materials, such as propane or liquefied petroleum gas, in a tank that has been used to store anhydrous ammonia.

When filling your anhydrous ammonia tank, do not fill it more than 85% full, and always disconnect the fill hose before moving the tank. Remember to bleed pressurized anhydrous ammonia from the hose before connecting or disconnecting the hose.

When transporting anhydrous ammonia, be sure to adhere to the following precautions and safety rules:

  • Running Gear: Regularly inspect the wagon’s frame tongue, reach poles, anchor devices, wheel bearings, knuckles, ball joints, and pins for structural damage and wear and make necessary repairs and adjustments.
  • Tires: Check tires for proper inflation, bald spots, and signs of wear and ensure that lug nuts are tight.
  • Hoses and Valves: Inspect and replace hoses and valves as needed.

    • The hydrostatic relief valve should be replaced every five years.
    • The transfer hose should be replaced five years from the date of manufacture.
  • Lubrication: Annually lubricate the wagon’s knuckle, wheels, tongues, and so on.
  • Towing Vehicle: To increase the driver’s ability to control the towing vehicle, ensure that the towing vehicle weighs at least as much as the tank.

    • A tractor can tow two tanks, but a truck can tow only one tank at a time.
  • Speed Limit: When towing an anhydrous ammonia tank, observe a speed limit of 25 mph.
  • Hitch Pin: Use a hitch pin with a safety chain when towing a tank wagon.
  • Warning Lights: Ensure that the tank is equipped with a seven-terminal breakaway connector plug to properly operate turn signals, flashing warning lights, and a red brake light.
  • Safety Signage: If operating on a highway, outfit the tank with all required safety markings, including a slow-moving vehicle (SMV) sign. (Click here for more information about SMV signs and increasing the visibility of your agricultural equipment.)

    • The words Anhydrous Ammonia must appear on both sides of the tank and on the rear of the tank in letters 4 in. high. The words should be in contrast to the tank so that they can be read easily.
    • Inhalation Hazard must appear on both sides of the tank in letters 3 in. high.  
    • A Department of Transportation (DOT) placard number 1005 for nonflammable gas should be placed on the front, back, and sides of the tank.


Additional Safety Recommendations

  • Paint the tank with reflective white paint to decrease excessive pressure buildup that can occur when the tank is heated from direct sunlight.
  • Do not use dented or damaged tanks until they have been checked by an authorized inspector and necessary repairs are completed.
  • Allow only certified welders to perform welding on the tank. 
  • Regulations and codes regarding towing of anhydrous ammonia and signage may vary, so be familiar with and obey the regulations in your state.


Use the following format to cite this article:


Anhydrous ammonia safety. (2012) Farm and Ranch eXtension in Safety and Health (FReSH) Community of Practice. Retrieved from



Schwab, C., Hanna, M., & Miller, L. (2008) Anhydrous ammonia safety: Play it safe with anhydrous ammonia. Iowa State University Extension and Outreach. Retrieved from

Training module: Safe handling of anhydrous ammonia (NH3). (2002) Ohio State University Extension. Retrieved from….

Training module: Towing anhydrous ammonia tanks. (2002) Ohio State University Extension Agricultural Tailgate Safety Training. Retrieved from


Reviewed and Summarized by:
LaMar Grafft, East Carolina University –
Linda M. Fetzer, Pennsylvania State University –
Dennis J. Murphy, Pennsylvania State University (Has since retired)
J. Samuel Steel, Pennsylvania State University (Has since retired)
Aaron M. Yoder, University of Nebraska Medical Center –